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| Glenn Close | Diana |
| Elizabeth Banks | Isabel |
| James Marsden | Jonathan |
| Jesse Bradford | Alec |
| Eric Bogosian | Henry |
| Matthew Davis | Mark |
| Andrew Howard | Ian |
| Thomas Lennon | Marshall |
| John Light | Peter |
| Susan Malick | Rachel |
| Michael Murphy | Jesse |
| Denis O'Hare | Andrew |
| Isabella Rossellini | Liz |
| George Segal | Rabbi Mendel |
| Rufus Wainwright | Jeremy |
| Chandler Williams | Juilliard Macbeth |
| Bess Wohl | Juilliard Lady Macbeth |
| Katie Kreisler | Helen |
Isabel, an aspiring photojournalist who pays her bills with weddings jobs, is unsure about her upcoming wedding to Jonathan, a Jewish lawyer. Her mother, Diana, an Oscar-winning actress, is becoming increasingly unhappy in her open marriage and has begun flirting with a much younger actor, Alec . Over a 24-hour period, Isabel, Diana and the people around them are forced to reevaluate their lives and their relationships.
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