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| Glenn Close | Diana |
| Elizabeth Banks | Isabel |
| James Marsden | Jonathan |
| Jesse Bradford | Alec |
| Eric Bogosian | Henry |
| Matthew Davis | Mark |
| Andrew Howard | Ian |
| Thomas Lennon | Marshall |
| John Light | Peter |
| Susan Malick | Rachel |
| Michael Murphy | Jesse |
| Denis O'Hare | Andrew |
| Isabella Rossellini | Liz |
| George Segal | Rabbi Mendel |
| Rufus Wainwright | Jeremy |
| Chandler Williams | Juilliard Macbeth |
| Bess Wohl | Juilliard Lady Macbeth |
| Katie Kreisler | Helen |
A famous actress, her daughter and several other New Yorkers face major life changes over the course of a day.
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