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| Meg Ryan | Eve |
| Diane Keaton | Georgia |
| Lisa Kudrow | Maddy |
| Walter Matthau | Lou |
| Adam Arkin | Joe |
| Duke Moosekian | Omar Kunundar |
| Ann Bortolotti | Ogmed Kunundar |
| Cloris Leachman | Pat |
| Maree Cheatham | Angie |
| Myndy Cryst | Dr. Kelly |
| Jesse James | Jesse |
| Tracee Ellis Ross | Kim |
| Ethan Dampf | Four Year Old Jesse |
Three sisters do what they do best with life, love, and lunacy on the telephone lines that bind- when their father is admitted to a Los Angeles Hospital. After years of wild living, intermittent affection, and constant phoning, he is finally threatening to die.
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