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| Meg Ryan | Eve |
| Diane Keaton | Georgia |
| Lisa Kudrow | Maddy |
| Walter Matthau | Lou |
| Adam Arkin | Joe |
| Duke Moosekian | Omar Kunundar |
| Ann Bortolotti | Ogmed Kunundar |
| Cloris Leachman | Pat |
| Maree Cheatham | Angie |
| Myndy Cryst | Dr. Kelly |
| Jesse James | Jesse |
| Tracee Ellis Ross | Kim |
| Ethan Dampf | Four Year Old Jesse |
Three sisters begin to bond after their curmudgeonly father, possibly near death, is admitted to the hospital.
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