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| Malcolm McDowell | Dr. Sam Loomis |
| Scout Taylor-Compton | Laurie Strode |
| Tyler Mane | Michael Myers - Adult |
| Danny Trejo | Ismael Cruz |
| Danielle Harris | Annie Brackett |
| Sheri Moon Zombie | Deborah Myers |
| William Forsythe | Ronnie White |
| Dee Wallace-Stone | Cynthia Strode |
| Kristina Klebe | Lynda |
| Jenny Gregg Stewart | Lindsey Wallace |
| Brad Dourif | Sheriff Brackett |
| Udo Kier | Morgan Walker |
| Daeg Faerch | Michael Myers - Child |
| Ken Foree | Big Joe Grizzley |
| Hanna Hall | Judith Myers |
| Pat Skipper | Mason Strode |
| Lew Temple | Nole Kluggs |
A psychiatrist follows an escaped psychopath's blood-soaked trail back to his hometown.
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