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| Liam Neeson | Charles ''Charlie'' Mayeaux |
| Oliver Platt | Fulvio Nesstra |
| Sandra Bullock | Judy Tipp |
| Jose Zuniga | Fidel Vaillar |
| Richard Schiff | Elliott |
| Andy Lauer | Jason Cane |
| Mitch Pileggi | Dexter Helvenshaw |
| Paul Ben-Victor | Howard |
| Mary McCormack | Gloria Nesstra |
| Frank Vincent | Carmine Minetti |
| Gregg Daniel | Jonathan |
| Michael DeLorenzo | Estuvio Clavo |
| Michael Mantell | Dr. Jeff Bleckner |
| Derek Anthony | |
| Michael Weatherly | Dave Juniper |
| Louis Giambalvo | Lonny Ward |
Legendary undercover DEA agent Charlie Mayough has suddenly lost his nerves of steel. On the verge of a career-induced mental breakdown, and in complete fear of trigger-happy Mafia leader Fulvio Nesstra, Charlie seeks psychiatric help and finds himself relying on the support of an unstable therapy group and nurse Judy just to get through his work.
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