| Gibson Gowland | John McTeague |
| ZaSu Pitts | Trina |
| Jean Hersholt | Marcus Schuller |
| Chester Conklin | 'Popper' Sieppe |
| Sylvia Ashton | Mommer' Sieppe |
| Oscar Gottell | A Sieppe twin (uncredited) |
| Otto Gottell | A Sieppe twin (uncredited) |
| Frank Hayes | Charles W. Grannis (proprietor, The Modern Dog Hospital) (uncredited) |
| Jack Curtis | McTeague Sr. (shift boss at the Big Dipper Mine) (uncredited) |
| Tempe Pigott | Mother McTeague |
| James F. Fulton | Cribbens (a prospector) (uncredited) |
| Jack McDonald | Placer County Sheriff (uncredited) |
| Dale Fuller | Maria Miranda Maccapa |
| Joan Standing | Selina |
| Austen Jewell | August Sieppe (uncredited) |
| Cesare Gravina | Zwerkow (a junkman) (uncredited) |
When housewife Trina McTeague wins the lottery, her comfortable life with her dentist husband, John, is slowly destroyed, in part by her own increasing paranoia and in part by the machinations of a villainous friend, Marcus . Director Erich von Stroheim shot the film, based on the Frank Norris novel ``McTeague'', on location in and around San Francisco, an extravagance unheard of in the 1920s. His original version, since lost, ran for nearly 10 hours.
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