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| John Travolta | Danny Zuko |
| Olivia Newton-John | Sandy Olsen |
| Stockard Channing | Rizzo |
| Jeff Conaway | Kenickie |
| Didi Conn | Frenchy |
| Eve Arden | Principal McGee |
| Sid Caesar | Coach Calhoun |
| Joan Blondell | Vi |
| Edd Byrnes | Vince Fontaine |
| Alice Ghostley | Mrs. Murdock |
| Dody Goodman | Blanche |
| Lorenzo Lamas | Tom Chisum |
| Michael Tucci | Sonny |
| Jamie Donnelly | Jan |
| Dinah Manoff | Marty Maraschino |
| Barry Pearl | Doody |
| Kelly Ward | Putzie |
| Susan Buckner | Patty Simcox |
| Annette Charles | Cha Cha DiGregorio |
| Dennis C. Stewart | Leo, Scorpions member |
| Eddie Deezen | Eugene Felnic |
Nice Sandy and greaser Danny try to be like each other in their 1950s high school.
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