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| Halle Berry | Dr. Miranda Grey |
| Robert Downey Jr. | (Dr. Pete Graham |
| Charles S. Dutton | |
| John Carroll Lynch | Sheriff Ryan |
| Bernard Hill | Phil Parsons |
| Penélope Cruz | Chloe Sava |
| Dorian Harewood | Teddy Howard |
| Bronwen Mantel | Irene |
| Kathleen Mackey | Rachel Parsons |
The life of psychiatrist Miranda Grey is derailed after she nearly hits a girl with her car one night. Later, Miranda wakes up in her own mental hospital under the care of her peer, Pete Graham . Completely disoriented, Miranda is accused of killing her own husband, but she has no memory of anything after she encountered the girl. Slowly Miranda begins to uncover what happened, but she has to escape the asylum to solve the mystery.
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