| David Strathairn | Edward R. Murrow |
| Patricia Clarkson | Shirley Wershba |
| George Clooney | Fred Friendly |
| Jeff Daniels | Sig Mickelson |
| Robert Downey Jr. | Joe Wershba |
| Frank Langella | William Paley |
| Ray Wise | Don Hollenbeck |
| Robert John Burke | Charlie Mack |
| Reed Diamond | John Aaron |
| Tate Donovan | Jesse Zousmer |
| Grant Heslov | Don Hewitt |
| Tom McCarthy | Palmer Williams |
| Matt Ross | Eddie Scott |
| Rose Abdoo | Millie Lerner |
| Alex Borstein | Natalie |
| Peter Jacobson | Jimmy |
| Robert Knepper | Don Surine |
| Dianne Reeves | Jazz singer |
CBS newsman Edward R. Murrow criticizes Sen. Joseph McCarthy's tactics in the 1950s, with the backing of producer Fred Friendly .
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