| Channing Tatum | Duke |
| Dennis Quaid | Hawk |
| Adewale Akinnuoye-Agbaje | Heavy Duty |
| Christopher Eccleston | Destro |
| Sienna Miller | The Baroness |
| Joseph Gordon-Levitt | Commander |
| Rachel Nichols | Scarlett |
| Ray Park | Snake Eyes |
| Saïd Taghmaoui | Breaker |
| Marlon Wayans | Ripcord |
| Byung-hun Lee | Storm Shadow |
Armed with the latest in military and spy technology, the team of elite soldiers known as G.I. Joe travel around the globe to wherever their services are needed. In their latest assignment Gen. Hawk, Duke and the rest of the G.I. Joe team take on Destro, a corrupt arms dealer, and fight the growing threat of the mysterious Cobra organization.
