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| Bill Murray | Doctor Peter Venkman |
| Dan Aykroyd | Doctor Raymond Stantz |
| Harold Ramis | Doctor Egon Spengler |
| Sigourney Weaver | Dana Barrett/Zuul, The Gate Keeper |
| Rick Moranis | Louis Tully/Vinz Clortho, The Key Master |
| Annie Potts | Janine Melnitz |
| William Atherton | Walter Peck |
| Ernie Hudson | Winston Zeddemore |
Parapsychologists with nuclear guns go into business ridding New York of poltergeists.
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