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| John Travolta | Chili Palmer |
| Gene Hackman | Harry Zimm |
| Rene Russo | Karen Flores |
| Danny DeVito | Martin Weir |
| Dennis Farina | Ray 'Bones' Barboni |
| Delroy Lindo | Bo Catlett |
| James Gandolfini | Bear |
| David Paymer | Leo Devoe |
| Martin Ferrero | Tommy Carlo |
| Miguel Sandoval | Mr. Escobar |
| Jon Gries | Ronnie Wingate |
| Linda Hart | Fay Devoe |
| Bette Midler | Doris Saphron |
| Harvey Keitel | Himself (uncredited) |
| Penny Marshall | Herself (Director) (uncredited) |
A film-loving loan shark teams with a B-movie producer to become a Hollywood mogul.
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