| Ethan Hawke | Vincent Freeman |
| Uma Thurman | Irene Cassini |
| Jude Law | Jerome Eugene Morrow |
| Gore Vidal | Director Josef |
| Alan Arkin | Det. Hugo |
| Loren Dean | Anton Freeman |
| Jayne Brook | Marie Freeman |
| Elias Koteas | Antonio Freeman |
| Chad Christ | Vincent Freeman - Teen |
| William Lee Scott | Young Anton |
| Tony Shalhoub | German |
| Ernest Borgnine | Caesar |
Vincent Freeman has always fantasized about traveling into outer space, but is grounded by his status as a genetically inferior ''in-valid.'' He decides to fight his fate by purchasing the genes of Jerome Morrow, a laboratory-engineered ''valid.'' He assumes Jerome's DNA identity and joins the Gattaca space program, where he falls in love with Irene . An investigation into the death of a Gattaca officer complicates Vincent's plans.
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