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| Jeffrey Combs | Crawford Tillinghast |
| Barbara Crampton | Dr. Katherine McMichaels |
| Ted Sorel | Dr. Edward Pretorius |
| Ken Foree | Leroy 'Bubba' Brown |
| Carolyn Purdy-Gordon | Dr. Bloch |
| Bunny Summers | Neighbor Lady |
| Bruce McGuire | Jordan Fields |
| Del Russel | Ambulance Driver |
| Dale Wyatt | Paramedic |
| Karen Christenfeld | Nurse |
| Andy Miller | Patient (Strait Jacket) |
| John Leamer | Shock Technician |
| Regina Bleesz | Bondage Girl |
Obsessive scientist Dr. Pretorius successfully discovers a way to access a parallel universe of pleasure by tapping into the brain's pineal gland. When he is seemingly killed by forces from this other dimension, his assistant, Dr. Crawford Tillinghast, is accused of the murder. After psychiatrist Katherine McMichaels and detective Bubba Brownlee take the case, the trio risks a return to the other world in order to solve the mystery.
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