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| Vince Vaughn | Fred Claus |
| Paul Giamatti | Nicholas |
| Miranda Richardson | Annette Claus |
| John Michael Higgins | Willie |
| Rachel Weisz | Wanda |
| Kevin Spacey | Clyde |
| Elizabeth Banks | Charlene |
| Kathy Bates | Mother Claus |
| Trevor Peacock | Papa Claus |
| Chris ``Ludacris'' Bridges | DJ Donnie |
| Rio Hackford | Leon |
| Bobb'e J. Thompson | Slam |
| Allan Corduner | Dr. Goldfarb |
Of the two Claus brothers, Fred is the troublemaker and polar opposite of his saintly sibling, Nicholas . When Fred's criminal ways finally land him in big trouble, Nicholas bails him out and brings him to the North Pole to work off the debt by making toys. The headaches mount for St. Nick, who not only must deal with his troublemaking brother, but also an efficiency expert who has come to evaluate Santa's operation.
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