| Lucille Ball | Susan Vega |
| Desi Arnaz | Lorenzo Xavier Vega |
| James Mason | The Guardian Angel |
| Louis Calhern | Charles Y. Bewell |
| John Emery | Dr. Edward R. Winter |
| John Hoyt | Bill Finlay |
| Natalie Schafer | Millie Opdyke |
| Mabel Albertson | Society Reporter |
| Ralph Dumke | Henry Opdyke |
| Nancy Kulp | Amy |
| Willis Bouchey | Mr. Oliver Clinton |
| Ruth Brady | Laura |
After five years of marriage, Susan and Lorenzo Vega have grown apart from each other. Lorenzo is a chemist who has been working long hours on a new insecticide, making Susan feel neglected. However, Susan starts seeing her Guardian Angel, who advises her to try to support her husband. So she agrees to go on a camping trip during which Lorenzo will be testing a new bug formula, even though Susan knows nothing about surviving outdoors.
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