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| John Wayne | Duke Fergus |
| Ann Dvorak | Ann ''Flaxen'' Tarry |
| Joseph Schildkraut | Boss Tito Morell |
| William Frawley | Wolf Wylie |
| Virginia Grey | Rita Dane |
| Russell Hicks | Cyrus Danver |
| Jack Norton | Byline Conners |
| Paul Fix | Calico Jim |
| Manart Kippen | Dr. Gorman |
| Marc Lawrence | Joe Disko |
| Butterfly McQueen | Beulah |
| Rex Lease | Collingswood |
| Hank Bell | Hank |
| Al Murphy | Horseshoe Brown |
| Adele Mara | Marie (uncredited) |
| Emmett Vogan | Gleason |
A Montana cattleman opens a casino and rivals a gambler for a singer in 1906 San Francisco.
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