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| Dionne Quintuplets | The Wyatt Quintuplets |
| Jean Hersholt | Dr. John Luke |
| Claire Trevor | Christine Nelson |
| Cesar Romero | Duke Lester |
| Slim Summerville | Jim Ogden |
| Henry Wilcoxon | Dr. Scott Williams |
| Inez Courtney | Libby Long |
| John Qualen | Asa Wyatt |
| Jane Darwell | Mrs. Waldron |
| Pauline Moore | Eleanor Kingsley |
| Andrew Tombes | Dr. Bruno |
| David Torrence | Sir Basil Crawford |
| Marion Byron | Nurse Corday |
| Hamilton MacFadden | Andrew Gordon |
| Spencer Charters | Rev. Matthew Brand |
| Charles D. Brown | Editor Crane |
Pursuing a story, reporter Chris Nelson reaches a source before competitor Duke Lester, then tries to scoop him. Unaware that it's a fabricated the story, she calls it in to her paper, and is subsequently fired when it runs and a lawsuit results. Inspired by a newsreel on the Canadian Wyatt Quintuplets, Chris proposes a radio program to another paper to rival Duke's. The show succeeds, and Duke races Chris to Canada to get the story first.
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