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| Stephen Boyd | Grant |
| Raquel Welch | Cora Peterson |
| Edmond O'Brien | General Carter |
| Donald Pleasence | Dr. Michaels |
| Arthur O'Connell | Colonel Donald Reid |
| William Redfield | Captain Bill Owens |
| Arthur Kennedy | Dr. Peter Duvall |
| Jean Del Val | Jan Benes |
| Barry Coe | Communications Aide |
| Ken Scott | Secret Service |
| Shelby Grant | Nurse |
| James Brolin | Technician |
| Brendan Fitzgerald | Wireless Operator |
A surgical task force is reduced to microbe size to perform a delicate operation inside the brain of a dying scientist.
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