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| Ioan Gruffudd | Reed Richards/Mr. Fantastic |
| Jessica Alba | Susan Storm/The Invisible Woman |
| Chris Evans | Johnny Storm/The Human Torch |
| Michael Chiklis | Ben Grimm/The Thing |
| Julian McMahon | Victor Von Doom/Doctor Doom |
| Hamish Linklater | Leonard |
| Kerry Washington | Alicia Masters |
| Stan Lee | Mailman Willy Lumpkin |
| Mark S. Allen | Ralph |
| Lorena Gale | Old Lady |
| G. Michael Gray | Boyfriend |
| Gina Holden | Receptionist |
| Laurie Holden | Debbie |
| Aonika Laurent | Bohemian |
Four people gain unusual powers after a space mission exposes them to cosmic radiation.
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