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| Jennifer Jason Leigh | Allegra Geller |
| Jude Law | Ted Pikul |
| Willem Dafoe | Gas |
| Ian Holm | Kiri Vinokur |
| Don McKellar | Yevgeny Nourish |
| Callum Keith Rennie | Hugo Carlaw |
| Sarah Polley | Merle |
| Christopher Eccleston | Seminar Leader |
| Robert A. Silverman | D'Arcy Nader |
| Oscar Hsu | Chinese Waiter |
| Kris Lemche | Noel Dichter |
| Vik Sahay | Male Assistant |
| Kirsten Johnson | Female Assistant |
| James Kirchner | Landry |
| Balazs Koos | Male Volunteer |
| Stephanie Belding | Female Volunteer |
| Gerry Quigley | Trout Farm Worker |
Video game designer Allegra Geller has created a virtual reality game called eXistenZ. After a crazed fan attempts to kill her, Allegra goes on the run with Ted, a young businessman who falls into the role of bodyguard. In an attempt to save her game, Allegra implants into Ted's body the video game pod that carries a damaged copy of eXistenZ. Allegra and Ted engage in a series of experiences that blur the lines between fantasy and reality.
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