| Steve Carell | Evan Baxter |
| Morgan Freeman | God |
| Lauren Graham | Joan Baxter |
| John Goodman | Congressman Long |
| Wanda Sykes | Rita |
| John Michael Higgins | Marty |
| Jonah Hill | Eugene |
| Molly Shannon | Eve Adams |
| Jimmy Bennett | Ryan Baxter |
| Johnny Simmons | Dylan Baxter |
| Graham Phillips | Jordan Baxter |
| Harve Presnell | Congressman Burrows |
| Rachael Harris | Markie Parkington |
| Ed Helms | Ed Carson |
| Jon Stewart | Himself |
Newscaster Evan Baxter leaves Buffalo behind when he wins a seat in Congress. Moving his wife and family to northern Virginia, he seems to have it made, then God throws a crisis of biblical proportions at his feet: The Lord wants him to build an ark and line up all the animals two-by-two in preparation for a flood.
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