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| Robert Downey Jr. | Peter Highman |
| Zach Galifianakis | Ethan Tremblay |
| Michelle Monaghan | Sarah Highman |
| Jamie Foxx | Darryl |
| Juliette Lewis | Heidi |
| Danny McBride | Lonnie |
| RZA | Airport Screener |
| Matt Walsh | TSA Agent |
Peter Highman will be a dad for the first time when his wife gives birth in five days. He intends to catch a flight home from Atlanta so he can be there for the delivery, but a chance encounter with aspiring actor Ethan Tremblay throws a monkey wrench into his plans. Desperate to reach his wife before their baby is born, Peter's sanity is tested when he must take a road trip cross-country with dog-toting Ethan.
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