| Basil Rathbone | Sherlock Holmes |
| Nigel Bruce | Dr. John H. Watson |
| Patricia Morison | Mrs. Hilda Courtney |
| Edmund Breon | Julian ``Stinky'' Emery |
| Frederick Worlock | Colonel Cavanaugh |
| Carl Harbord | Inspector Hopkins |
| Patricia Cameron | Evelyn Clifford |
| Tom Dillon | Detective Sergeant Thompson |
| Harry Cording | Hamid |
| Topsy Glyn | The Kilgour Child |
| Mary Gordon | Mrs. Hudson |
| Ian Wolfe | Commissioner of Scotland Yard |
| Lillian Bronson | Minister's Wife |
Holmes and Watson hunt for three music boxes containing directions to the whereabouts of six valuable engraving plates stolen from the Bank of England. They find themselves in competition with professional thieves also out to find the clues, which were hidden by a spiteful jailbird before the music boxes went up for auction.
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