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| Jamie Foxx | Curtis Taylor Jr. |
| Beyoncé Knowles | Deena Jones |
| Eddie Murphy | James `Thunder' Early |
| Jennifer Hudson | Effie White |
| Anika Noni Rose | Lorrell Robinson |
| Keith Robinson | C.C. White |
| Hinton Battle | Wayne |
| Sharon Leal | Michelle Morris |
| Danny Glover | Marty Madison |
| John Lithgow | Jerry Harris |
| Dawnn Lewis | Melba Early |
| John Krasinski | Sam Walsh |
Deena,Effie and Lorrell form a music trio called the Dreamettes. When ambitious manager Curtis Taylor Jr. spots the act at a talent show, he offers the chance of a lifetime, to be backup singers for a national star . Taylor takes creative control of the group and eventually pushes the singers into the spotlight. However, one becomes the star, forcing another out, which teaches them about the high cost of fame.
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