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| Meryl Streep | Sister Aloysius |
| Philip Seymour Hoffman | Father Flynn |
| Amy Adams | Sister James |
| Viola Davis | Mrs. Muller |
| Alice Drummond | Sister Veronica |
| Audrie Neenan | Sister Raymond |
| Susan Blommaert | Mrs. Carson |
| Carrie Preston | Christine Hurley |
| John Costelloe | Warren Hurley |
| Lloyd Clay Brown | Jimmy Hurley |
| Joseph Foster | Donald Miller |
| Bridget Megan Clark | Noreen Horan |
| Lydia Jordan | Alice |
| Mike Roukis | William London |
In 1964 the winds of change are sweeping through Sister Aloysius' St. Nicholas school. Father Flynn, a charismatic priest, is advocating reform of the school's strict customs, and the first black student has just been accepted. When a fellow nun tells Sister Aloysius that Father Flynn may be paying too much personal attention to the student, Sister Aloysius begins a personal crusade against the priest -- despite her lack of evidence.
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