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| Keira Knightley | Domino Harvey |
| Mickey Rourke | Ed Mosbey |
| Edgar Ramirez | Choco |
| Delroy Lindo | Claremont Williams |
| Lucy Liu | Taryn Miles |
| Christopher Walken | Mark Heiss |
| Mena Suvari | Kimmie, Assistant TV Producer |
| Mo'Nique | Lateesha Rodriguez |
| Macy Gray | Lashindra Davis |
| Jacqueline Bisset | Pauline Stone, Domino's mother |
| Dabney Coleman | Drake Bishop |
| Brian Austin Green | Himself |
| Ian Ziering | Himself |
| Stanley Kamel | Anthony Cigliutti |
| Peter Jacobson | Burke Beckett |
| T.K. Carter | Lester Kincaid |
| Kel O'Neill | Francis |
| Shondrella Avery | Lashandra Davis |
| Lew Temple | Locus Fender |
| Tom Waits | Wanderer |
| Jerry Springer | Himself |
| Charles Paraventi | Howie Stein |
Domino Harvey turns her back on wealth and privilege for the excitement of life as a bounty hunter.
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