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| Dennis Quaid | Dexter Cornell |
| Meg Ryan | Sydney Fuller |
| Charlotte Rampling | Mrs. Fitzwaring |
| Daniel Stern | Hal Petersham |
| Jane Kaczmarek | Gail Cornell |
| Christopher Neame | Bernard |
| Robin Johnson | Cookie Fitzwaring |
| Rob Knepper | Nicholas Lang |
| Jay Patterson | Graham Corey |
| Brion James | Detective Ulmer |
| Jack Kehoe | Detective Brockton |
| Elizabeth Arlen | Elaine Wells |
| Karen Radcliffe | Jane Corey |
| William Forward | Chief Resident |
| Lee Gideon | Mr. Fitzwaring |
| Bill Bolender | Nick Lang Sr. |
| Hillary Hoffman | Corey's Daughter |
| John Hawkes | Sloane |
A professor and a coed spend his final hours trying to find out who has slipped him luminous poison.
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