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| Matthew Broderick | Cooper |
| Alan Alda | Rollie |
| Virginia Madsen | Charlotte |
| Louis C.K. | Stan |
| Jimmy Bennett | Dillon |
| Dylan Baker | Mad Dog McClure |
| Bobby Cannavale | Lee Vivyan |
| Jim True-Frost | Donny Prine |
Suffering from concussion-induced memory loss, Chicago newspaper editor Cooper heads to his Missouri hometown for a much-needed break. Discovering that his beloved Uncle Rollie is not only suffering from Alzheimer's but is also facing eviction, Cooper pledges to help the old man.
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