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| Walter Matthau | Mr. George Wilson |
| Mason Gamble | Dennis Mitchell |
| Joan Plowright | Mrs. Martha Wilson |
| Christopher Lloyd | Switchblade Sam (Town Robber) |
| Lea Thompson | Mrs. Alice Mitchell |
| Robert Stanton | Mr. Henry Mitchell |
| Paul Winfield | Chief of Police |
| Amy Sakasitz | Margaret Wade |
| Kellen Hathaway | Joey |
| Billie Bird | Edith Butterwell |
| Arnold Stang | Photographer |
The comic-strip moppet plays pranks on Mr. Wilson, the crotchety fellow who lives next door.
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