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| Steve Carell | Dan |
| Juliette Binoche | Marie |
| Dane Cook | Mitch |
| Alison Pill | Jane |
| Dianne Wiest | Nana |
| John Mahoney | Poppy |
| Emily Blunt | Ruthie Draper |
| Brittany Robertson | Cara |
| Marlene Lawston | Lilly |
| Norbert Leo Butz | Clay |
| Amy Ryan | Eileen |
| Jessica Hecht | Amy |
| Frank Wood | Howard |
| Henry Miller | Will |
| Ella Miller | Rachel |
Dan Burns, a widower and advice columnist, meets a beautiful stranger in a bookstore and is instantly smitten. Unfortunately the woman, named Marie, is already involved with Dan's charismatic brother . As a weekend family gathering gets underway, Dan and Marie try to hide their mutual attraction, but fall in love anyway.
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