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| Keanu Reeves | John Constantine |
| Rachel Weisz | Angela Dodson/Isabel Dodson |
| Shia LaBeouf | Chas Chandler |
| Djimon Hounsou | Papa Midnite |
| Max Baker | Beeman |
| Pruitt Taylor Vince | Father Hennessy |
| Gavin Rossdale | Balthazar (as Gavin Rossdale) |
| Tilda Swinton | Gabriel |
| Peter Stormare | Satan |
| Jesse Ramirez | Scavenger |
| Michelle Monaghan | Ellie |
| Larry Cedar | Vermin Man |
| Suzanne Whang | Mother |
| Johanna Trias | Possessed Girl |
A man who can see demons helps a skeptical policewoman investigate her twin sister's mysterious death.
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