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| Nicolas Cage | Cameron Poe |
| John Cusack | U.S. Marshal Vince Larkin |
| John Malkovich | Cyrus 'The Virus' Grissom |
| Steve Buscemi | Garland 'The Marietta Mangler' Greene |
| Ving Rhames | Nathan 'Diamond Dog' Jones |
| Colm Meaney | DEA Agent Duncan Malloy |
| Mykelti Williamson | Mike 'Baby-O' O'Dell |
| Rachel Ticotin | Guard Sally Bishop |
| Monica Potter | Tricia Poe |
| Dave Chappelle | Joe ``Pinball'' Parker |
| M. C. Gainey | Swamp Thing |
| John Roselius | Skip Devers |
| Renoly | Ramon Martinez |
| Danny Trejo | Johnny 'Johnny-23' Baca |
| Jesse Borrego | Francisco Cindino |
| Nick Chinlund | William 'Billy Bedlam' Bedford |
| Angela Featherstone | Ginny |
| Jose Zuniga | DEA Agent Willie Sims |
| Landry Allbright | Casey Poe |
A wrongly convicted parolee on a flight with a group of vicious prisoners tries to stop their violent hijacking.
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