| Paul Giamatti | Paul |
| Dina Korzun | Nina |
| Emily Watson | Claire |
| David Strathairn | Dr. Flintstein |
| Lauren Ambrose | Stephanie |
| Katheryn Winnick | Sveta |
| Boris Kievsky | Oleg |
| Oksana Lada | Sasha |
| Natalia Zvereva | Anastasia |
| Rebecca Brooksher | Yelena |
Paul, an actor, is having trouble preparing for the title role in Chekhov's ``Uncle Vanya.'' A magazine article puts him in touch with Dr. Flintstein, who specializes in the extraction and exchange of souls. Paul receives the essence of a Russian poet and is a rousing success onstage, but offstage, his new soul is taking over his life. A black-market courier named Nina joins forces with Paul on a journey to Russia to find his lost soul.
