| Pam Grier | Coffy |
| Booker Bradshaw | Howard Brunswick |
| Robert DoQui | King George |
| William Elliott | Carter |
| Allan Arbus | Arturo Vitroni |
| Sid Haig | Omar |
| Barry Cahill | McHenry |
| Morris Buchanan | Sugarman |
| Lee de Broux | Nick |
| Bob Minor | Studs |
| John Perak | Aleva |
| Ruben Moreno | Ramos |
| Carol Lawson | Priscilla |
| Linda Haynes | Meg |
| Lisa Farringer | Jeri |
A nurse seeks revenge on those she holds responsible for her 11-year-old sister's drug addiction.
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