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| Pam Grier | Coffy |
| Booker Bradshaw | Howard Brunswick |
| Robert DoQui | King George |
| William Elliott | Carter |
| Allan Arbus | Arturo Vitroni |
| Sid Haig | Omar |
| Barry Cahill | McHenry |
| Morris Buchanan | Sugarman |
| Lee de Broux | Nick |
| Bob Minor | Studs |
| John Perak | Aleva |
| Ruben Moreno | Ramos |
| Carol Lawson | Priscilla |
| Linda Haynes | Meg |
| Lisa Farringer | Jeri |
As a nurse, Coffy has seen the ill effects of drugs up close, but it isn't until her little sister becomes addicted to heroin that she finally decides to wage a one-woman battle. Disguised as a prostitute, Coffy goes on a killing rampage, at first going after street dealers and pimps such as sleazy King George, then gradually working her way up to bigger honchos. She's shocked, however, when she discovers that her politician boyfriend is involved.
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