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| Roberto Benigni | Roberto |
| Steven Wright | Steven |
| Joie Lee | Good Twin |
| Cinqué Lee | Evil Twin |
| Steve Buscemi | Waiter |
| Iggy Pop | Iggy |
| Tom Waits | Tom |
| Vinny Vella | Vinny |
| Vinny Vella Jr. | Vinny Jr. |
| Renee French | Renée |
| E.J. Rodriguez | Waiter |
| Alex Descas | Alex |
| Isaach De Bankolé | Isaach |
| Cate Blanchett | Cate/Shelly |
| Meg White | Meg |
| Jack White | Jack |
| Alfred Molina | Alfred |
| Steve Coogan | Steve |
| Bill Murray | Bill Murray |
| Taylor Mead | Taylor |
| Joseph Rigano | Joe |
| RZA | RZA |
| Bill Rice | Bill |
| GZA | GZA |
Vignettes revolve around a dentist appointment, a talkative waiter, musicians and celebrities.
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