| John Ritter | Clifford the Big Red Dog |
| Wayne Brady | Shackelford |
| Jenna Elfman | Dorothy |
| John Goodman | George Wolfsbottom |
| Jess Harnell | Dirk |
| Kel Mitchell | T-Bone |
| Judge Reinhold | Larry |
| Kath Soucie | Jetta / Madison |
| Cree Summer | Cleo |
| Wilmer Valderrama | Rodrigo |
A gigantic red dog leaves home and becomes the main attraction at a traveling circus.
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