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| Catherine Zeta-Jones | Velma Kelley |
| Renée Zellweger | Roxie Hart |
| Richard Gere | Billy Flynn |
| Queen Latifah | Matron Marna Morton |
| John C. Reilly | Amos Hart |
| Christine Baranski | Mary Sunshine |
| Lucy Liu | Kitty Baxter |
| Taye Diggs | Bandleader |
| Colm Feore | Harrison |
| Dominic West | Fred Casely |
| Denise Faye | Annie |
| Mya Harrison | Mona |
| Susan Misner | Liz |
| Ekaterina Chtchelkanova | Ikanova Hunyak |
| Deidre Goodwin | June |
A lawyer handles the cases of two murderous women who are looking to gain celebrity from their public exposure.
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