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| Cheech Marin | Cheech/Dwayne ``Red'' Mendoza |
| Thomas Chong | Chong |
| Paul Reubens | Pee-wee Herman/Desk Clerk |
| Evelyn Guerrero | Donna |
| Betty Kennedy | Candy |
| Sy Kramer | Mr. Neatnik |
| Rikki Marin | Gloria |
| Edie McClurg | Gloria's Mom |
| Bob McClurg | Chicken Charlie |
Perennially stoned Cheech and Chong tear through the city of Los Angeles, causing trouble wherever they go. After Cheech loses his job, the two pot enthusiasts head to the welfare offices where Cheech's girlfriend, Donna, works. Instead of collecting unemployment, they find themselves thrown back on the streets, searching for a way to earn new income. But when Cheech's cousin, ''Red'' Mendoza, arrives, things get even crazier.
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