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| Steve Martin | Tom Baker |
| Bonnie Hunt | Kate Baker |
| Piper Perabo | Nora Baker |
| Tom Welling | Charlie Baker |
| Hilary Duff | Lorraine Baker |
| Alyson Stoner | Sarah Baker |
| Jacob Smith | Jake Baker |
| Liliana Mumy | Jessica Baker |
| Morgan York | Kim Baker |
| Forrest Landis | Mark Baker |
| Blake Woodruff | Mike Baker |
| Brent Kinsman | Nigel Baker |
| Shane Kinsman | Kyle Baker |
| Paula Marshall | Tina Shenk |
| Steven Anthony Lawrence | Dylan Shenk |
| Alan Ruck | Bill Shenk |
| Richard Jenkins | Shake |
| Regis Philbin | Himself |
| Kelly Ripa | Herself |
| Kevin G. Schmidt | Henry Baker |
While his wife is away on business, a college-football coach must handle the chaos surrounding his 12 children.
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