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| Benicio Del Toro | Ernesto 'Che' Guevara de la Serna |
| Demián Bichir | Fidel Castro |
| Santiago Cabrera | Camillo Cienfuegos |
| Elvira Mínguez | Celia Sanchez |
| Franka Potente | Tania |
| Jorge Perugorría | Joaquin |
| Edgar Ramirez | Ciro Redondo |
| Victor Rasuk | Rogelio Acevedo |
| Armando Riesco | Benigno |
| Catalina Sandino Moreno | Aleida Guevara |
| Rodrigo Santoro | Raul Castro |
| Unax Ugalde | Little Cowboy |
| Yul Vazquez | Alejandro Ramirez |
| Carlos Bardem | Moises Guevara |
| Joaquim de Almeida | Barrientos |
| Lou Diamond Phillips | Mario Monje |
| Julia Ormond | Lisa Howard |
| Kahlil Mendez | Urbano |
| Jordi Mollà | Capt. Vargas |
Ernesto ``Che'' Guevara transforms himself from an intellectual, asthmatic doctor to one of Latin America's most legendary revolutionaries. Che, joining forces with Fidel Castro, brings down the Batista government in Cuba in 1958. However, his attempt to bring the Cuban revolution to Bolivia meets with disaster.
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