| Benicio Del Toro | Ernesto 'Che' Guevara de la Serna |
| Demián Bichir | Fidel Castro |
| Santiago Cabrera | Camillo Cienfuegos |
| Elvira Mínguez | Celia Sanchez |
| Franka Potente | Tania |
| Jorge Perugorría | Joaquin |
| Edgar Ramirez | Ciro Redondo |
| Victor Rasuk | Rogelio Acevedo |
| Armando Riesco | Benigno |
| Catalina Sandino Moreno | Aleida Guevara |
| Rodrigo Santoro | Raul Castro |
| Unax Ugalde | Little Cowboy |
| Yul Vazquez | Alejandro Ramirez |
| Carlos Bardem | Moises Guevara |
| Joaquim de Almeida | Barrientos |
| Lou Diamond Phillips | Mario Monje |
| Julia Ormond | Lisa Howard |
| Kahlil Mendez | Urbano |
| Jordi Mollà | Capt. Vargas |
Ernesto ``Che'' Guevara transforms from an intellectual, asthmatic doctor to one of Latin America's most legendary revolutionaries. In the years before his famous 1964 visit to the United Nations, Che joins forces with Cuban exile Fidel Castro and ignites a revolution that eventually brings an end to the Batista regime in Cuba.
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