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| Jeff Goldblum | Professor Brody |
| Elizabeth Perkins | Carolyn Brody |
| Miriam Margolyes | Sophie the Castle Maid |
| Alexander Pollock | Scott Brody |
| Tobey Maguire | Lou |
| Alec Baldwin | Butch |
| Sean Hayes | Mr. Tinkles |
| Susan Sarandon | Ivy |
| Joe Pantoliano | Peek |
| Michael Clarke Duncan | Sam |
| Jon Lovitz | Calico |
| Charlton Heston | Mastiff |
| Salome Jens | Collie at HQ |
| Glenn Ficarra | Russian Blue |
| Danny Mann | Ninja cat |
| Billy West | Ninja cat |
``Cats & Dogs'' uncovers the truth about the high-tech, secret war being waged in neighborhoods everywhere that humans aren't even aware of: an eternal struggle between the two great armies of Cats and Dogs. The story follows a Cat plan to destroy a new vaccine that, if developed, would destroy all human allergies to Dogs, and the Dogs' efforts to stop the Cats from executing their plan.
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