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| Robert De Niro | Sam 'Ace' Rothstein |
| Sharon Stone | Ginger McKenna/Rothstein |
| Joe Pesci | Nicky Santoro |
| James Woods | Lester Diamond |
| Don Rickles | Billy Sherbert |
| Alan King | Andy Stone |
| Kevin Pollak | Phillip Green |
| L.Q. Jones | Pat Webb |
| Dick Smothers | Senator |
| Frank Vincent | Frank Marino |
| John Bloom | Don Ward |
| Pasquale Cajano | Remo Gaggi |
| Melissa Prophet | Jennifer Santoro |
| Bill Allison | John Nance |
| Vinny Vella | Artie Piscano |
| Oscar Goodman | Himself |
| Catherine Scorsese | Piscano's Mother |
| Phillip Suriano | Dominick Santoro |
| Erika von Tagen | Amy Rothstein (Older) |
| Frankie Avalon | Himself |
| Steve Allen | Himself |
| Jayne Meadows | Herself |
| Jerry Vale | Himself |
A New York bookie and his pal turn a Las Vegas casino into an empire, then one's money-hungry wife helps bring it down.
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