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| Owen Wilson | Lightning McQueen |
| Paul Newman | Doc Hudson |
| Bonnie Hunt | Sally |
| Larry the Cable Guy | Mater |
| Katherine Helmond | Lizzie |
| Cheech Marin | Ramon |
| Richard Petty | The King |
| Michael Keaton | Chick Hicks |
| John Ratzenberger | Mack |
| Tony Shalhoub | Luigi |
| Bob Costas | Bob Cutlass |
| Ray Magliozzi | Clunk |
| Tom Magliozzi | Clink |
| Guido Quaroni | Guido |
| Darrell Waltrip | Darrell Cartrip |
While traveling to California to race against The King and Chick Hicks for the Piston Cup Championship, Lightning McQueen becomes lost after falling out of his trailer in a run down town called Radiator Springs. While there he slowly befriends the town's odd residents, including Sally, Doc Hudson and Mater . When it comes time for him to leave to championship is no longer his top priority.
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