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| Lou Taylor Pucci | Danny |
| Chris Pine | Brian |
| Piper Perabo | Bobby |
| Emily VanCamp | Kate |
| Christopher Meloni | Frank |
| Kiernan Shipka | Jodie |
When a virus threatens to wipe out humanity, Danny, his brother Brian, and their friends Bobby and Kate set out across the desert in the Southwest, trying to elude the pandemic. Over the course of several days, the four friends learn that the darkness within themselves may prove deadlier than any microbe.
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