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| Adrien Brody | Leonard Chess |
| Beyoncé Knowles | Etta James |
| Jeffrey Wright | Muddy Waters |
| Gabrielle Union | Geneva |
| Columbus Short | Little Walter |
| Cedric the Entertainer | Willie Dixon |
| Eamonn Walker | Howlin' Wolf |
| Emmanuelle Chriqui | Revetta Chess |
| Mos Def | Chuck Berry |
In 1947 Chicago, Polish emigrant and bar owner Leonard Chess hires a blues combo that includes guitarist Muddy Waters and harmonica player Little Walter . Waters' and Walter's success leads to Chess' management of stars Etta James, Howlin' Wolf, Chuck Berry and others. Inevitably, business and personal lines blur as the sometimes-turbulent lives of the musicians play out.
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