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| George Clooney | Harry Pfarrer |
| Frances McDormand | Linda Litzke |
| John Malkovich | Osborne Cox |
| Tilda Swinton | Katie Cox |
| Brad Pitt | Chad Feldheimer |
| Richard Jenkins | Ted |
| Elizabeth Marvel | Sandy Pfarrar |
| David Rasche | CIA Officer |
| J.K. Simmons | CIA Superior |
| Jeffrey DeMunn | Cosmetic Surgeon |
When a disc containing memoirs of a former CIA analyst falls into the hands of Linda Litzke and Chad Feldheimer, the two gym employees see a chance to make enough money for her to have life-changing cosmetic surgery. Predictably, events whirl out of control for the duo doofuses and those in their orbit.
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