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| Rene Russo | Mrs. Gertrude ``Trudy'' Lintz |
| Robbie Coltrane | Dr. Bill Lintz |
| Alan Cumming | Dick Croner, Trudy's Assistant |
| Irma P. Hall | Emma, Lintz's Maid |
| Paul Reubens | Professor Spatz |
| John Aylward | Mr. Joe Bowman |
| Mimi Kennedy | Mrs. Bunny Bowman |
| Jon Simmons | Theatergoer |
| Kathleen Klein | Movie Woman |
| Russell Young | Usher |
| Frank Collison | Zoo Keeper |
| Al Weber | Barker |
| Philip Baker Hall | Minister |
| Kyle Galyean | Bellowing Man |
| Dane Cook | Fair Cop |
| Michael Reid Mackay | Skinny Man |
| John Ennis | Policeman |
| Jeff Hatz | Policeman |
| Bradley J. Lesley | Ali Baba |
| Julianna Wheeler | Cornered Woman |
Thanks to the indulgence of her patient husband, Dr. Bill Lintz, wealthy eccentric Trudy has already accumulated a large collection of wild animals by 1931 when she is introduced to Buddy, a sickly young gorilla. Trudy raises Buddy as her own child, dressing him in human clothes, and the ape responds with absolute obedience. But as Buddy grows older and larger, Trudy is unable to restrain him from turning increasingly violent.
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