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| Jake Gyllenhaal | Jimmy Livingston |
| Swoosie Kurtz | Mrs. Livingston |
| Marley Shelton | Chloe |
| Danny Trejo | Slim |
| John Carroll Lynch | Mr. Livingston |
| Verne Troyer | Dr. Phreak |
| Dave Sheridan | Mark |
| Brian George | Pushpak |
| Patrick Cranshaw | Pappy/Pippy |
| Stephen Spinella | Chicken Man |
| Ever Carradine | Mark's Sister |
| Geoffrey Arend | Flipper Boy |
| Beetlejuice | Li'l Zip |
| Matthew McGrory | Human Sasquatch |
| Bonnie Morgan | Rubber Woman |
| Jason Sklar | Shlomo |
| Fabio | Gil |
| Ping Wu | Emcee |
| Zach Galifianakis | Bus Stop Man |
| Boti Ann Bliss | Cashier |
| Pablo Schreiber | Todd |
| Brian Gattas | Todd |
| Cinco Paul | Todd |
| Ken Daurio | Todd |
| Malik Toure | Todd |
| Leo Fitzpatrick | Todd |
| J.P. Coe | Todd |
| R.J. Durell | Todd |
| Brian Friedman | Todd |
| Arden Myrin | Lorraine |
A teen in a special suit embarks on a cross-country trip to stop the girl he loves from getting married.
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