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| Anthony Hopkins | John Casey |
| Harry Belafonte | Nelson |
| William H. Macy | Paul |
| Sharon Stone | Miriam |
| Christian Slater | Timmons |
| Freddy Rodriguez | Jose |
| Laurence Fishburne | Edward Robinson |
| Demi Moore | Virginia Fallon |
| Emilio Estevez | Tim Fallon |
| Martin Sheen | Jack |
| Helen Hunt | Samantha |
| Lindsay Lohan | Diane |
| Elijah Wood | William |
| Nick Cannon | Dwayne |
| Heather Graham | Angela |
| Ashton Kutcher | Pusher |
| David Krumholtz | Phil |
| Shia LaBeouf | Jimmy |
| Joy Bryant | Patricia |
| Brian Geraghty | Jimmy |
| Joshua Jackson | Wade |
| Svetlana Metkina | Lenka Janacek |
| Jacob Vargas | Miguel |
| Mary Elizabeth Winstead | Susan Taylor |
In 1968 the lives of a retired doorman, hotel manager, lounge singer, busboy, beautician and others intersect in the wake of Robert F. Kennedy's assassination at the Ambassador Hotel in Los Angeles.
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